Table 1.

Anticancer agents inducing replication stress (based on [35]).

DNA-Targeting Agents	Representative Drugs	Target	Mechanism of Action
Alkylating agents	Cisplatine Carboplatine Oxaliplatine	DNA template damage	Inter-strand crosslinks
	Temozolomide	DNA template damage MGMT	O6-alkyl-guanine lesions on DNA
TOP I and II inhibitors	Irinotecan Topotecan Etoposide Doxorubicin Mitoxantrone	DNA template damage	Block the re-ligation of the TOP-DNA cleavage complexes
PARP inhibitors	Olaparib Rucaparib Niraparib Talazoparib Veliparib	DNA template damage by defective single-strand breaks repair	Generating toxic PARP-DNA complexes
Nucleoside analogs	Gemcitabine Cytarabine 5-azacytidine	DNA elongation inhibition	Blocking DNA polymerase or reducing the pool of nucleotides

Abbreviations: TOP = topoisomerase; PARP = poly (ADP-ribose) polymerase; DNA = deoxyribonucleic acid; MGMT = DNA-repair protein O⁶ methylguanine-DNA methyltransferase.