Table 1.
Hormonal and reproductive | Early age of the first menstruation |
Late age of the last menstruation | |
The first reported pregnancy at a late age (after 30 years of age) | |
No pregnancies | |
Postmenopausal condition | |
Use of oral contraception | |
Use of hormone replacement therapy | |
Related to physiological factors and health status | Older age (increased risk from 35 years of age) |
Family history of breast cancer | |
Breast, ovarian and endometrial cancer in the past | |
Occurrence of benign changes in the breasts, proceeding with the presence of atypical hyperplasia | |
Ionizing radiation, used in connection with, for example, Hodgkin lymphoma therapy | |
Rapid growth in adolescence and high growth in adulthood | |
Infection with an oncogenic virus (e.g., Epstein–Barr) | |
Nutritional | Western type diet |
Excessive consumption of fats, especially animal fats | |
High consumption of red and fried meat | |
High iron intake | |
Development of overweight/obesity after menopause | |
Low consumption of fresh vegetables and fruits | |
Low intake of phytoestrogens (isoflavones, lignans) | |
Other lifestyle-related | Regular moderate/high alcohol consumption |
Lack of regular physical activity | |
Night work |