Table 5.

HER-2 receptor IHC rating scale, interpretation.

Result	Interpretation
0—no reaction or color reaction in the <10% of infiltrating cancer cells	Negative state
1+—discontinuous coloration, complete membrane staining in the <10% of infiltrating cancer cells	Negative state
2+—weak or medium complete membrane staining in >/= 10% of infiltrating cancer cells	Ambiguous (borderline) state, requires in situ hybridization of the same material or reassessment of IHC or ISH from other material of the examined tumor
3+—Strong complete membrane staining in >/= 30% of infiltrating cancer cells	Positive state