Table 3.
Reproductive and oncological outcomes of patients after undergoing fertility-sparing surgical procedure.
| Type of Cancer | Author | Treatment | Patients | Reproductive Outcomes | Oncological Outcomes | ||||
|---|---|---|---|---|---|---|---|---|---|
| Total | TTC (%) | N° Pregnancies | ART Pregnancies | LBR (%) | Recurrence (%) | Death (%) | |||
| Cervical cancer | Bentivegna et al. 2016 | ST | 212 | NA | 103 | NA | 74.0 | NA | NA |
| VRT | 1355 | NA | 499 | NA | 67.0 | NA | NA | ||
| RT (lptm) | 735 | NA | 175 | NA | 68.0 | NA | NA | ||
| RT(MIS) | 314 | NA | 74 | NA | 78.0 | NA | NA | ||
| NACT | 161 | NA | 93 | NA | 76.0 | NA | NA | ||
| Willows et al. 2016 | RT (a-b: lesion </> 2 cm) | 1238 (a) | 44 | 469 | NA | 66.7 | 4.5 | 1.7 | |
| 134 (b) | 30 | 10 | 70.0 | 11.1 | 4.2 | ||||
| Non-radical FSS | 124 | NA | 71 | NA | 67.6 | 2.7 | 0.5 | ||
| NACT | 62 | NA | 36 | NA | 72.2 | 6.3 | 1.3 | ||
| Nezhat et al. 2020 | ST/CKC | 283 | 29.3 | 131 | 8 | 86.4 | 1.4 | 0.2 | |
| VRT | 1387 | 43.8 | 606 | 78 | 63.4 | 3.7 | 1.1 | ||
| AbRT | 1060 | 43 | 229 | 104 | 65.7 | 3.6 | 0.7 | ||
| RT (MIS) | 314 | 22.6 | 81 | 16 | 56.5 | 3.3 | 0.1 | ||
| Schuurman et al. 2021 | LLETZ/CKC/ST | 612 | 48.5 | 241 | NA | 77.4 | 3.6 | 0.8 | |
| VRT | 1539 | 55 | 707 | NA | 70.6 | 4.2 | 1.7 | ||
| AbRT (lptm) | 1635 | 48 | 353 | NA | 58 | 3.1 | 1.5 | ||
| RT (MIS) | 344 | 35.7 | 81 | NA | 71.6 | 4.5 | 1.5 | ||
| Endometrial cancer | Park et al. 2013 | Progestin therapy (PG) | 141 | 49.6 | 51 | 44 | 66.0 | 31.9 | 0 |
| Harrison et al. 2019 | PG: alone (1); followed by hysterectomy (2) | 421 (1) | NA | 131 | 65 | 11.6 | NA | NA | |
| 397 (2) | NA | 34 | 216 | 52.0 | NA | NA | |||
| Leone et al. 2019 | LNG-IUD | 44 | 43.1 | 14 | 8 | 23.4 | 41.5 | NA | |
| Schuurman et al. 2021 | FSS/PG/LNG | 505 | 62.6 | 256 | NA | 72 | 34.7 | 0.8 | |
| Ovarian cancer | Bentivegna et al. 2016 | Conservative surgery * | 651 (EOC) | 42.8 | 323 | NA | 69.0 | 12 | 6 |
| Tamauchi et al. 2018 | Conservative surgery | 105 (OGCT) | 42.8 | 65 | 7 | 64.6 | 10.4 | 3.8 | |
| Plett et al. 2020 | Conservative surgery | 95 (BOT) | 43.1 | 48 | NA | 79.0 | 13 | NA | |
| Bercow et al. 2021 | Conservative surgery | 614 (EOC) | 50 | 242 | NA | 76–96 | 5–18 | 8.8 | |
| 992 (BOT) | NA | 657 | NA | 23–100 | 11.6 | 2.3 | |||
| Schuurman et al. 2021 | Conservative surgery | 750 | 44.2 | 280 | NA | 89.4 | 15.7 | 14.7 | |
Note: TTC: trying to conceive; ART: reproductive assisted techniques; LBR: live birth rate; NA: not available; ST: simple trachelectomy VRT—vaginal radical trachelectomy; RT: radical trachelectomy; NACT: neoadjuvant chemotherapy CK: cold knife conization; AbRT: abdominal radical trachelectomy; MIS: minimal invasive surgery (laparoscopic or robotassisted); LLETZ: large loop excision of transformation zone; lptm: laparotomy; EOC: epitelian ovarian cancer; BOT: borderline ovarian tumor; OGCT: ovarian germ cell tumor. *: considered as the preservation of at least one ovary and the uterus.