BC	Breast cancer
HER-2+ BC	Human epidermal growth factor receptor-2 overexpressing breast cancer
NPs	Nanoparticles
EGFR	Epidermal growth factor receptor
AKT	Protein kinase B, PKB
PI3K	Phosphoinositide 3-kinase
MAPK	Mitogen-activated protein kinase
IHC	Immunohistochemistry
FISH	Fluorescence in situ hybridization
mAb	Monoclonal antibodies
TZ	Trastuzumab
DFS	Disease-free survival
OS	Overall survival
ADCC	Antibody-Dependent Cellular Cytotoxicity
T-DM1, Kadcyla®	Trastuzumab emtansine
ADCs	Antibody-drug conjugates, anticancer drugs
PFS	Progression-free survival
PTEN	Phosphatase and tensin homolog
TKIs	Tyrosine kinase inhibitors
pCR	Pathological complete response
TILs	Tumor-infiltrating lymphocytes
PEI	Polyethylenimine
PLGA	Poly (D,L-lactide-co-glycolide)
sdAb	Single-domain antibodies
VH	Human immunoglobulin heavy chain
Fab	Antibody fragments
TmAb	Fab obtained by papain cleavage of TZ
PmAb	Fab obtained by papain cleavage of panitumumab
scFv	Single chain variable fragments
DOX	Doxorubicin
PTX	Paclitaxel
PCI	Photochemical Internalization
siRNA	Short interfering RNA
PTT	Photothermal therapy
GNRs	Gold nanorods
AuNPs	Gold nanoparticles
PK	Pharmacokinetic
XBP1	X-box binding protein 1
PDT	Photodynamic therapy
Hapt	Aptamer
IHC	Immunohistochemistry
CISH	Chromogenic in-situ hybridization
CT	Computerized tomography
PET	Positron emission tomography
SPECT	Single photon emission computed tomography
US	Ultrasounds
MRI	Magnetic resonance imaging
SPIONs	Super paramagnetic iron oxide nanoparticles
FGS	Fluorescence guided surgery
QDs	Quantum dots
Cy	Cyanine
BSA	Bovine serum albumin
EPR	Enhanced Permeation and Retention
PAMAM	Polyamidoamine
SERS	Surface-enhanced Raman scattering
SELEX	Systematic evolution of ligands by exponential enrichment