Table 1.

ROC curve analysis for miRNAs with biomarker potential and their 95% CI.

miRNAs	Profiling Study Fold Change	Validation Study Fold Change		Sensitivity (%)	Specificity (%)	AUC	95% CI	p-Value	Corrected p-Value
		Controls (n = 17) Mean ± SE	Cases (n = 18) Mean ± SE
miR-19b-3p	2.03	1.1 ± 0.13	1.5 ± 0.11	77.78	64.71	0.7059	0.5267 to 0.8850	0.0017	0.037
miR-33a-5p	2.04	2.3 ± 0.67	6.7 ± 0.84	77.78	82.35	0.8578	0.7320 to 0.9837	0.0001	0.0003
miR-130b-3p	3.29	1.3 ± 0.33	7.3 ± 2.4	66.67	68.75	0.7778	0.6204 to 0.9352	0.0048	0.027
miR-136-3p	2.34	1.6 ± 0.39	2.9 ± 0.33	73.33	82.35	0.7882	0.6192 to 0.9573	0.0045	0.022
miR-210-3p	5.85	1.2 ± 0.19	2.2 ± 0.24	66.67	70.59	0.7810	0.6233 to 0.9387	0.0039	0.004

CI = confidence interval. ROC = Receiver operating characteristic curve; SE = standard error; AUC = area under the ROC curve.