Table 1.

Recent advances in PARP inhibitor therapy, adapted from Gupta and colleagues [90].

Investigators	Phase	Patient Population	Number of PDAC Patients	Intervention	Outcome	Ref
Kauffman et al.	II	PDAC with gBRCA1/2 mutation following progression on gemcitabine	23	Olaparib 400mg PO BID	ORR 22% PFS 4.6 months OS 9.8 months	[91]
Shroff et al.	II	PDAC with any BRCA mutation, previously treated with 1-2 lines	19	Rucaparib 600mg PO BID	ORR 16%	[83]
Lowery et al.	II	PDAC with gBRCA mutation or PALB2 mutation, 1-2 prior lines of treatment	16	Veliparib PO BID PO	PFS 1.7 months OS 3.1 months	[85]
Golan et al.	II	PDAC with BRCA-appearing phenotype, first or second line	32	Olaparib PO BID	PFS 14 weeks in Israel 25 weeks in the US	[81]
Golan et al.	III	PDAC with gBRCA mutation that has not progressed on firstline platinum-based treatment	92 olaparib 62 placebo	3:2 olaparib versus placebo	ORR 37%	[80]
Reiss et al.	II	PDAC with g or s BRCA or PALB2 mutations that has not progressed on firstline platinum-based treatment	24	Rucaparib 600mg PO BID	ORR 37%	[82]
Chiorean et al.	II	PDAC including g or s BRCA or PALB2 mutations	108	1:1 veliparib + FOLFIRI versus FOLFIRI alone	OS 5.1 vs 5.9 months PFS 2 months vs 3 months	[92]
Pishvaian et al	I/II	PDAC with g or S BRCA or PALB2 mutations or relevant breast or ovarian family history	22	Veliparib + mFOLFOX6	OS 8.5 months PFS 3.7 months	[93]