Figure 2.

(a) Cellular uptake of Lu-177-DOTATE (50 kBq) for 1 h in HEKsst₂ and PC3 cells and (b) 24 h. Before uptake analysis both cell lines were pretreated with 5-aza-dC and VPA over a time period of 5 days as described above. Unstimulated controls (con) were simultaneously incubated with Lu-177-DOTATATE. The intracellular activity is normalized to results in unstimulated control cells. Results are expressed as changes in percentage in relation to results without stimulation. All data are shown as mean ± SD.