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. 2022 May 13;13:819826. doi: 10.3389/fphar.2022.819826

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Copyright © 2022 Li, Yang, Yuan, Lin, Tian, Li, Zhang, Wang, Xie, Wang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IR ameliorates UC in mice by regulating OSM/OSMR pathway. (A) The protein levels of OSM and OSMR in colon of mice detected by western blotting, with gray intensity analysis shown in panel (B,C). (D) Cell viability of Caco2 cells treated with different concentrations of LPS for 24 h. (E) Cell viability of Caco2 cells treated with different concentrations of IR for 24 and 48 h. (F) The expression of OSM, OSMR, and IL-6 proteins of Caco2 cells detected by western blotting after 1 μg/ml LPS stimulated, with gray intensity analysis shown in panel (G–I). (J) The effect of IR on the expression of OSM and OSM proteins of Caco2 cells after LPS stimulated, with gray intensity analysis shown in panel (K,L). All data were compared using one-way ANOVA, and p-values reflected differences between experimental groups (n = 3).