Figure 1.

Overview of data source, source population and study sample (dashed arrows show linkages between databases using personal health numbers which are then de-identified/scrambled). The risk set refers to individuals without a history of depression or anxiety and are therefore considered at risk for incident depression or anxiety and included in the study sample for each respective analysis. Abbreviations: CRC—colorectal cancer; yCRC—young-onset colorectal cancer; aCRC—average-age-onset colorectal cancer; PHN—personal health number.