Figure 2.

Different structures of TAM family kinase inhibitors. TAM receptors are divided into three groups, based on their base core structure: CORE-A compounds, with hydrogen bond acceptor–substituted phenyl group linked to a hinge-binding heterocycle with a solubilising group; CORE-B compounds, with heterocycle (hinge-binding) optionally ortho-fluoro phenyl group (binding DFG motif), 2–4 hydrogen donors/acceptors, and a phenyl group (or para-fluoro phenyl) (binding to allosteric hydrophobic pockets); and CORE-X compounds, that cannot be clearly assigned to either -A, or -B groups, as they present only partial structural similarity to other cores, or present completely different lead structures. Compounds approved for treatment are presented in bold, compounds currently in clinical trials are presented in italics, and compounds that did not enter the clinical phase are presented in plain text.