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. 2022 May 13;10:841523. doi: 10.3389/fcell.2022.841523

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Copyright © 2022 Yang, Guo, Feng, Liu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial quality control system. Damaged mitochondrial fragment splits from healthy mitochondrion by fission and then degrades by mitophagy. Mitochondrial fusion assembles healthy mitochondria and maintains the normal function of mitochondria. Abbreviations: Opa1, optic atrophy 1, Mfn, mitofusin, DRP1, Dynamin-related protein 1, LC3, microtubule-associated protein 1A/1B-light chain 3, PINK, PTEN-induced kinase 1, Δψm, mitochondrial membrane potential.