Table 4. MANCOVA analysis of the relationship between the FC according to the interaction analysis between the spectrum of responders or nonresponders on the CPM-test by psychiatric disorders according to the MINI (n = 37).
| (A) Main effects | ||||||||
| Dependent Variable | Type III Sum of Squares | df | Mean Square | F | Sig. | Partial Eta Squared | ||
| Left prefrontal cortex–Left motor cortex | 0.266 | 3 | 0.089 | 3.957 | 0.016 | 0.265 | ||
| Left prefrontal cortex–Right prefrontal cortex | 0.061 | 3 | 0.02 | 0.688 | 0.566 | 0.059 | ||
| Left prefrontal cortex–Right motor cortex | 0.066 | 3 | 0.022 | 1.057 | 0.381 | 0.088 | ||
| Left motor cortex–Right prefrontal cortex | 0.25 | 3 | 0.083 | 3.856 | 0.018 | 0.26 | ||
| Left motor cortex–Right motor cortex | 0.107 | 3 | 0.036 | 0.857 | 0.473 | 0.072 | ||
| Right prefrontal cortex–Right motor cortex | 0.076 | 3 | 0.025 | 0.779 | 0.514 | 0.066 | ||
| Conditioned pain modulation | ||||||||
| Left prefrontal cortex–Left motor cortex | 0.134 | 1 | 0.134 | 5.987 | 0.02 | 0.154 | ||
| Left prefrontal cortex–Right prefrontal cortex | 0.046 | 1 | 0.046 | 1.544 | 0.223 | 0.045 | ||
| Left prefrontal cortex–Right motor cortex | 0.005 | 1 | 0.005 | 0.265 | 0.610 | 0.008 | ||
| Left motor cortex–Right prefrontal cortex | 0.17 | 1 | 0.17 | 7.868 | 0.008 | 0.193 | ||
| Left motor cortex–Right motor cortex | 0.056 | 1 | 0.056 | 1.352 | 0.253 | 0.039 | ||
| Right prefrontal cortex–Right motor cortex | 0.009 | 1 | 0.009 | 0.273 | 0.605 | 0.008 | ||
| Interaction analysis according to CPM-test categories classified in responders⁄ nonresponders | ||||||||
| * Multiple psychiatric disorders according to the MINI | ||||||||
| Left prefrontal cortex–Left motor cortex | 0.116 | 2 | 0.058 | 2.591 | 0.09 | 0.136 | ||
| Left prefrontal cortex–Right prefrontal cortex | 0.04 | 2 | 0.02 | 0.669 | 0.519 | 0.039 | ||
| Left prefrontal cortex–Right motor cortex | 0.000 | 2 | 8.988E-005 | 0.004 | 0.996 | 0.000 | ||
| Left motor cortex–Right prefrontal cortex | 0.118 | 2 | 0.059 | 2.719 | 0.081 | 0.141 | ||
| Left motor cortex–Right motor cortex | 0.031 | 2 | 0.016 | 0.38 | 0.687 | 0.022 | ||
| Right prefrontal cortex–Right motor cortex | 0.03 | 2 | 0.015 | 0.455 | 0.638 | 0.027 | ||
| B. Coefficient | ||||||||
| β | Std. Error | t | Sig. | CI 95% | Partial Eta Squared | |||
| Left prefrontal cortex–Left motor cortex: Dependent Variable | ||||||||
| Intercept | 1.135 | 0.179 | 6.356 | 0.000 | (0.771 to 1.498) | 0.550 | ||
| Responders⁄ Nonresponders to CPM test | -0.516 | 0.211 | -2.447 | 0.02 | (-0.946 to -0.087) | 0.154 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | -0.006 | 0.065 | -0.097 | 0.924 | (-0.14 to 0.127) | 0.000 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | -0.222 | 0.097 | -2.275 | 0.03 | (-0.42 to -0.023) | 0.136 | ||
| Left prefrontal cortex–Right prefrontal cortex: Dependent Variable | ||||||||
| Intercept | 1.007 | 0.206 | 4.896 | 0.000 | (0.589 to 1.426) | 0.421 | ||
| Responders⁄ Nonresponders to CPM test | -0.302 | 0.243 | -1.243 | 0.223 | (-0.797 to 0.193) | 0.045 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | 0.014 | 0.075 | 0.189 | 0.852 | (-0.139 to 0.168) | 0.001 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | -0.128 | 0.112 | -1.142 | 0.262 | (-0.357 to 0.1) | 0.038 | ||
| Left prefrontal cortex–Right motor cortex: Dependent Variable | ||||||||
| Intercept | 0.619 | 0.172 | 3.599 | 0.001 | (0.269 to 0.969) | 0.282 | ||
| Responders⁄ Nonresponders to CPM test | -0.105 | 0.203 | -0.514 | 0.610 | (-0.518 to 0.309) | 0.008 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | 0.004 | 0.063 | 0.068 | 0.946 | (-0.124 to 0.133) | 0.000 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | -0.006 | 0.094 | -0.063 | 0.950 | (-0.197 to 0.185) | 0.000 | ||
| Left motor cortex–Right prefrontal cortex: Dependent Variable | ||||||||
| Intercept | 1.025 | 0.175 | 5.838 | 0.000 | (0.667 to 1.382) | 0.508 | ||
| Responders⁄ Nonresponders to CPM test | -0.582 | 0.207 | -2.805 | 0.008 | (-1.004 to -0.16) | 0.193 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | 0.05 | 0.064 | 0.775 | 0.444 | (-0.081 to 0.181) | 0.018 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | -0.211 | 0.096 | -2.2 | 0.035 | (-0.406 to -0.016) | 0.128 | ||
| Left motor cortex–Right motor cortex: Dependent Variable | ||||||||
| Intercept | 0.772 | 0.243 | 3.175 | 0.003 | (0.277 to 1.266) | 0.234 | ||
| Responders⁄ Nonresponders to CPM test | -0.334 | 0.287 | -1.163 | 0.253 | (-0.919 to 0.250) | 0.039 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | 0.049 | 0.089 | 0.547 | 0.588 | (-0.133 to 0.230) | 0.009 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | -0.09 | 0.133 | -0.678 | 0.502 | (-0.360 to 0.180) | 0.014 | ||
| Right prefrontal cortex–Right motor cortex: Dependent Variable | ||||||||
| Intercept | 0.558 | 0.216 | 2.589 | 0.014 | (0.119 to 0.997) | 0.169 | ||
| Responders⁄ Nonresponders to CPM test | -0.133 | 0.255 | -0.522 | 0.605 | (-0.652 to 0.385) | 0.008 | ||
| Responders to CPM test* Multiple psychiatric disorders according to the MINI | 0.072 | 0.079 | 0.912 | 0.369 | (-0.089 to 0.233) | 0.025 | ||
| Nonresponders to CPM test* Multiple psychiatric disorders according to the MINI | 0.033 | 0.118 | 0.281 | 0.780 | (-0.206 to 0.273) | 0.002 | ||
a R2 adjusted = 0.198
b R2 adjusted = -0.027
c R2 adjusted = 0.005
d R2 adjusted = 0.192
e R2 adjusted = - 0.012
f R2 adjusted = -0.019.