Table 4. Cox regression model for the outcome of the composite endpoint.

Measures	COVID-19				Viral controls				Bacterial controls
	n = 191				n = 227				n = 96
	Univariable		Multivariable		Univariable		Multivariable		Univariable		Multivariable
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
IL-6	6.602 (3.113–14.003)	<0.001	6.602 (3.113–14.003)	<0.001	3.630 (1.602–8.227)	0.002	-	-	2.277 (1.200–4.321)	0.012	2.101 (1.042–4.239)	0.038
CRP	5.519 (2.187–13.932)	<0.001	-	-	7.651 (1.562–37.48)	0.012	7.651 (1.562–37.480)	0.012	2.484 (0.914–6.754)	0.075	3.091 (0.839–11.393)	0.090
PCT	2.796 (1.476–5.297)	0.002	-	-	3.445 (1.414–8.394)	0.006	-	-	1.862 (1.064–3.258)	0.029	-	-
Ferritin	4.397 (1.632–11.845)	0.003	-	-	0.927 (0.126–6.811)	0.941	-	-	0.558 (0.215–1.449)	0.231	0.290 (0.082–1.022)	0.054
Leukocytes	5.066 (0.834–30.771)	0.078	-	-	10.899 (0.027–4377.491)	0.435	-	-	0.710 (0.099–5.116)	0.734	-	-

p-values for comparison of HR were calculated using the log-rank test

values were logarithmized to approach a normal distribution, values for the multivariable model were selected using a backwards selection process

HR = hazard ratio, CI = confidence interval, IL-6 = interleukin-6, CRP = c-reactive protein, PCT = procalcitonin.