Figure 3:

Box plots of serum etonogestrel concentrations for therapeutic participants at each time point in the study. Therapeutic participants are defined as those reaching a serum topiramate concentration of ≥5 microgram/mL during the study. The box represents the first and third quartiles (IQRs [interquartile range]; 118.0–177.5, 96.0–147.0, 92.6–138.0, 82.8–126.5) with the band inside the box representing the median (142.0, 125.0, 119.0, 95.0). Whiskers represent the data within 1.5 IQR of the upper and lower quartile, or if no value exists within that range, then to the minimum or maximum values. Red dotted line marks the threshold for consistent ovulatory suppression (90 pg/mL). Outliers are represented by open circles (outside 1.5 times the IQR). Extreme outliers (outside 3 times the IQR) excluded from the figure (participant 48 visit 1 [771 pg/mL] and participant 27 visit 4 [859 pg/mL]).