Table 2.

Ozone and non-surgical periodontal therapy for mucositis and peri-implantitis.

Article	Follow-Up	Problem	Intervention	Control	Outcomes
McKenna et al., 2013 [13]	21 days	Mucositis	Ozone and saline (1) Ozone and hydrogen peroxide (3)	Hydrogen peroxide and air (2) Air and saline (4)	Significant differences were seen among the treatments (p < 0.01) in plaque (F = 16.68), modified gingival (F = 7.86), and bleeding (F = 18.42) indices. O3 + saline and O3 + H2O2 produced optimum gingival health scores
Butera et al., 2021 [33]	2 months	Mucositis	Professional oral hygiene + ozonized water	Professional oral hygiene + pure water	As regards intragroup differences, in Group 1 ozonized water significantly and progressively reduced all the clinical indexes tested, except for PI in the period T1–T2, whereas no significant differences occurred within the control group