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. 2022 May 23;11(10):1517. doi: 10.3390/foods11101517

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SBO synergizes the DTX effect via cell cycle arrest and senescence in NSCLC. (a) The cell cycle distribution treated with SBO (1 mg/mL) solely or co-treated with DTX (0.1 nM) was assessed by flow cytometry analysis after 24 h of exposure. (b,c) Quantitative data of the percentage of the cell populations in G0/G1, S, and G2/M phases. Data are expressed as mean ± SD. (d) A549, H23 cells were seeded in 24-well plates cultured in fresh medium for 72 h and treated with SBO (1 mg/mL) and/or DTX (0.1 nM) for another 72 h. The phase-contrast analysis and SA-β-gal assay were performed. Representative images were photographed under a light microscopic analysis to show SA-β-gal positive cells (blue cells). The scale bar represents 100 µm.

SBO synergizes the DTX effect via cell cycle arrest and senescence in NSCLC. (a) The cell cycle distribution treated with SBO (1 mg/mL) solely or co-treated with DTX (0.1 nM) was assessed by flow cytometry analysis after 24 h of exposure. (b,c) Quantitative data of the percentage of the cell populations in G0/G1, S, and G2/M phases. Data are expressed as mean ± SD. (d) A549, H23 cells were seeded in 24-well plates cultured in fresh medium for 72 h and treated with SBO (1 mg/mL) and/or DTX (0.1 nM) for another 72 h. The phase-contrast analysis and SA-β-gal assay were performed. Representative images were photographed under a light microscopic analysis to show SA-β-gal positive cells (blue cells). The scale bar represents 100 µm.