Table 2.
Combination index (CI) values at different levels of growth inhibition induced by SBO merged with DTX.
| Cell Line | SBO (mg/mL) | DTX 0.0 nM | DTX 0.1 nM | DTX 0.5 nM | DTX 1 nM |
|---|---|---|---|---|---|
| A549 | 0.0 | 2.1 ± 3.4 | 1.7 ± 2.9 | 6.0 ± 6.3 | |
| 0.5 | 10.9 ± 1.5 | 10.4 ± 1.6 (1.06) | 16.2 ± 1.0 (0.64) | 17.4 ± 1.2 (0.6) | |
| 1 | 19.8 ± 2.5 | 24.6 ± 3.2 (0.7) | 22.4 ± 4.6 (0.86) | 24.9 ± 2.8 (0.8) | |
| H23 | 0.0 | 3.0 ± 2.8 | 9.2 ± 1.6 | 14.0 ± 2.1 | |
| 0.5 | 22.8 ± 2.7 | 23.2 ± 4.3 (1.0) | 27.7 ± 1.4 (0.6) | 30.8 ± 3.6 (0.5) | |
| 1 | 26.5 ± 7.7 | 32.9 ± 4.0 (0.37) | 35.2 ± 2.9 (0.4) | 38.8 ± 1.1 (0.3) |
Values were expressed as mean ± SD (n = 3). Values in brackets are combination indexes (CI < 1, synergism; CI = 1, additive effect; CI > 1, antagonism).