Table 2.
MIC for hybrid peptides.
| Sequence of Hybrid Peptides and Folding Patterns Predicted by AlphaFold 2 |
Strain of the Pathogenic Microorganism | MIC for the Tested Hybrid Peptide (µM) |
|---|---|---|
| Based on the sequence S1 protein from P. aeruginosa | ||
RKKRRQRRRGGGGITDFGIFIGL 
|
MRSA strain ATCC 43,300 (resistant to ampicillin) S. | 12 |
| aureus strain 209 (resistant to aztreonam) | >12 | |
| P. aeruginosa (strain ATCC 28,753) (resistant to sulfamethoxazole) | 12 | |
RKKRRQRRRGGSarGLHITD-Nle-AWKR 
|
P. aeruginosa (strain ATCC 28,753) (resistant to sulfamethoxazole) | 12 |
| P. aeruginosa (strain PA 103) (resistant to levomycetin) | >12 | |
RKKRRQRRRGGSarGITDFGIFIGL 
|
P. aeruginosa (strain ATCC 28,753) (resistant to sulfamethoxazole) | 12 |
| P. aeruginosa (strain PA 103) (resistant to levomycetin) | >12 | |
| Based on the sequence S1 protein from S. aureus | ||
RKKRRQRRRGGSarGVVVHI-Asi-GGKF 
|
MRSA strain ATCC 43,300 (resistant only to ampicillin) | 3 |
| S. aureus strain 209 (resistant to aztreonam) | 3 | |
| P. aeruginosa strain ATCC 28,753 (resistant to sulfamethoxazole) | 12 | |
RKKRRQRRRGGSarGLTQFGAFIDI 
|
MRSA strain ATCC 43,300 (resistant only to ampicillin) | 3 |
| S. aureus strain 209 (resistant to aztreonam) | 6 | |
| P. aeruginosa strain ATCC 28,753 (resistant to sulfamethoxazole) | 12 | |
RKKRRQRRRGGSarGVQGLVHISEI 
|
MRSA strain ATCC 43,300 (resistant only to ampicillin) | 6 |
| S. aureus strain 209 (resistant to aztreonam) | 12 | |
| P. aeruginosa strain ATCC 28,753 (resistant to sulfamethoxazole) | >12 | |