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. 2022 May 10;13(5):846. doi: 10.3390/genes13050846

Figure 3.

Figure 3

Silence of hsa_circ_0006692 inhibited the proliferation, migration, and invasiveness of A549 and H1299 cells. (A) qPCR on hsa_circ_0006692 expression in A549 and H1299 cells. (B,C) The roles of hsa_circ_0006692 silencing in the vitality of A549 and H1299 cells measured using the MTS assay; (D,E) The roles of hsa_circ_0006692 silencing in the colony formation of A549 and H1299 cells; (F,G) The roles of hsa_circ_0006692 knockdown in cell cycle distribution of A549 and H1299 cells measured with FACS; (L–O) The roles of hsa_circ_0006692 silencing in the migration of A549 and H1299 cells measured with wound healing assay; (P,Q) The roles of hsa_circ_0006692 silencing in the invasiveness of A549 and H1299 cells measured with the transwell invasive assay; (H–K) The expression of proliferation-related-genes BCL-2, CCND1, and PCNA were detected by qRT-PCR and WB; (R,S) The expression of EMT-associated genes, MMP7, VIMENTIN, CDH1, and CDH2 demonstrated by WB. *** p < 0.001; **** p < 0.0001.