| AD | Alzheimer’s disease |
| α2-AR | α2-adrenoceptors |
| BBB | blood−brain barrier |
| Cl | plasma clearance |
| Cmax | maximum observed concentration |
| HLM | human liver microsomes |
| I2-IR | imidazoline I2 receptors |
| LPS | bacterial lipopolysaccharide |
| MLM | mouse liver microsomes |
| MRM | reaction monitoring mode |
| ND | neurodegenerative diseases |
| 6-OHDA | 6-hydroxydopamine |
| PAMPA | parallel artificial membrane permeability assay |
| PD | Parkinson’s disease |
| PK | pharmacokinetics |
| SAMP8 | senescence-accelerated mouse prone 8 |
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