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. 2022 May 13;23(10):5459. doi: 10.3390/ijms23105459

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The proposed model for truncated O-glycan-containing MUC16 facilitates α4β1 integrin signaling. Interaction between Tn/STn-MUC16 and the α4β1 integrin complex facilitates activation of the integrin-linked kinase (ILK) and focal adhesion kinase (FAK) axis to increase migratory behavior in PDAC (indicated by green arrows). Blocking the integrin signaling using the BTT 3033 inhibitor or MUC16 signaling using the monoclonal antibody, AR9.6, dampens the ILK-FAK cascade and decreases cell migration (indicated by red arrows).