Table 4.
Top 20 ranked novel hubs ranked based on their functional similarities to known GWA IPF genes. Upregulated and downregulated hubs are ranked separately.
| Rank | Upregulated Hub Genes | Description | Downregulated Hub Genes | Description |
|---|---|---|---|---|
| 1 | CHEK2 | Checkpoint kinase 2 | CTNND2 | Catenin delta 2 |
| 2 | CDH3 | Cadherin 3 | CDH13 | Cadherin 13 |
| 3 | COL7A1 | Collagen type VII alpha 1 chain | SELENBP1 | Selenium binding protein 1 |
| 4 | CFI | Complement factor I | ARHGAP31 | Rho GTPase activating protein 31 |
| 5 | KCND3 | Potassium voltage-gated channel subfamily D member 3 | CAVIN2 | Caveolae associated protein 2 |
| 6 | CRABP2 | Cellular retinoic acid binding protein 2 | DENND3 | DENN domain containing 3 |
| 7 | ZNF469 | Zinc finger protein 469 | SLC1A1 | Solute carrier family 1 member 1 |
| 8 | STEAP2 | STEAP2 metalloreductase | EMP2 | Epithelial membrane protein 2 |
| 9 | TDO2 | Tryptophan 2,3-dioxygenase | PAPSS2 | 3′-phosphoadenosine 5′-phosphosulfate synthase 2 |
| 10 | SEC24D | SEC24 homolog D, COPII coat complex component | SLC44A2 | Solute carrier family 44 member 2 |
| 11 | CLMP | CXADR like membrane protein | N4BP1 | NEDD4 binding protein 1 |
| 12 | DCLK1 | Doublecortin like kinase 1 | GPM6A | Glycoprotein M6A |
| 13 | MAGED4B | MAGE family member D4B | NINJ2 | Ninjurin 2 |
| 14 | PDIA4 | Protein disulfide isomerase family A member 4 | RRAS | RAS related |
| 15 | ITGA7 | Integrin subunit alpha 7 | HPCAL1 | Hippocalcin like 1 |
| 16 | NPM3 | Nucleophosmin/nucleoplasmin 3 | AFF3 | AF4/FMR2 family member 3 |
| 17 | COL10A1 | Collagen type X alpha 1 chain | NDRG4 | NDRG family member 4 |
| 18 | GPX8 | Glutathione peroxidase 8 (putative) | VIPR1 | Vasoactive intestinal peptide receptor 1 |
| 19 | EFNA4 | Ephrin A4 | MYRF | Myelin regulatory factor |
| 20 | DOK5 | Docking protein 5 | RS1 | Retinoschisin 1 |