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. 2022 May 10;23(10):5333. doi: 10.3390/ijms23105333

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of early life stress on BDNF transcript levels. (A,B) Maternally separated rats had higher levels of Bdnf IIA and III mRNAs in the substantia nigra and VTA than control rats; (C) there were no main effects of early life stress on Bdnf transcripts in the dorsal striatum; (D) maternally separated rats had lower levels of Bdnf I, IIA, IIC, IV and VI mRNAs in the ventral striatum than control rats. Data are expressed as a percentage of the control group mean. Each data point represents a single animal. Filled triangles and hollow circles represent control and early life stress animals, respectively. Horizontal lines depict group means. * p < 0.05, ** p < 0.005.