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Effect of Oxy210 on glucocorticoid (GR) and mineralocorticoid receptor (MR) activity. The GR and MR activity assays were performed as described in Materials and Methods using the compounds as indicated. Dexamethasone and aldosterone were used as positive controls for GR and MR, respectively.
| GR-Agonism | MR-Agonism | |
|---|---|---|
| Dexamethasone (10 µM) | 100% | - |
| Dexamethason (0.4 µM) | 100% | - |
| Aldosteron (1 µM) | - | 100% |
| Aldosteron (0.04 µM) | - | 100% |
| Oxy210 (10 µM) | 1% | −3.6% |
