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. 2022 May 23;12(5):1291. doi: 10.3390/diagnostics12051291

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Decision tree for FFPE DNA. This figure describes the decision tree based on the pre-analytical and post-analytical parameters observed in 144 DNA samples. DIN, DNA concentration, and library concentration are found to be the predictive parameters while implementing targeted NGS in diagnostic settings. The first QC checkpoint is at the preanalytical phase consisting of DIN and DNA concentration. The second QC is at the library concentration of DNA samples. Implementing both QC checks can predict the outcome of FFPE DNA-based NGS for a targeted panel in a diagnostics setting.