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While much is unknown about the mechanism by which mutant Reelin leads to ADLTE, decreased serum levels in ADLTE patients suggested causal roles. It is hypothesized that Reelin is also decreased in the brain of these patients, affecting processes such as neuronal migration, synaptic potentiation, and dendritic growth, which could result in the development of ADLTE. Created with BioRender.com (accessed on 27 February 2022).
