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. 2022 May 19;13(5):910. doi: 10.3390/genes13050910

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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m¹A-modifying proteins for different types of RNAs. The nuclear-encoded (top panel) and mitochondrial (bottom panel) RNAs are reversibly methylated by m¹A methyltransferases (blue; dark blue represents catalytic core of the methylase complex), demethylased by m¹A demethylases (pink), and bound by m¹A-dependent RNA-binding proteins (green). A, adenosine; m¹A, N¹-methyladenosine; TRMT, tRNA (adenine (58)-N (1))-methyltransferase subunit; ALKBH, α-ketoglutarate-dependent dioxygenase alkB homolog; FTO, α-ketoglutarate-dependent dioxygenase alkB homolog FTO; NML, nucleomethylin; YTHDF, YTH domain-containing family protein; YTHDC1, YTH domain-containing protein 1; SDR5C1, 3-hydroxyacyl-CoA dehydrogenase type-2.