Figure 4.

Neutralisation of variants of concern

(A) NT₅₀ values for variant pseudoviruses alpha (B.1.1.7), alpha with a Glu484Lys, beta (B.1.351) version 1, beta version 2, or delta (B.1.617.2) measured at indicated timepoints, normalised to wild type NT₅₀; analysis done in a cohort of 58 participants; statistical significance was determined with Wilcoxon test; dotted line indicates a ratio of 1 (equal NT₅₀). (B) Correlation coefficients (Spearman's r values) of NT₅₀ values between original and variant viruses and each serological assay, measured at visit 1 and visit 5; analysis done in 58 participants for all groups shown, except for DiaSorin S1/S2 (n=54). N=nucleocapsid. NT₅₀=half-maximal neutralisation titre. RBD=receptor binding domain. S=spike protein. sVNT₅₀=50% surrogate virus neutralisation titer.