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(A): pedigree of patient with novel c.401-1G>A PROC gene splice site mutation. The mutation carriers marked with grey and the proband indicated with an arrow. DVT denotes deep vein thrombosis; PAD, peripheral arterial disease; MI, myocardial infarction. (B): demographic and laboratory data for the subjects available for genetic and biochemical analyses. The reference ranges: PC activity, 70–140%; total protein C, 60–140%.
