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. 2022 May 15;23(10):5524. doi: 10.3390/ijms23105524

Figure 5.

Figure 5

Augmented lung localization and survival rate after tail-vein injection of radioresistant (RR)-CaSki cells in BALB/c nude mice, and exogenous administration of miR-29a remarkedly abridged the radioresistance-enhanced lung localization. Wild-type (WT)-CaSki cells (green fluorescence) and RR-CaSki cells (red fluorescence) were mixed in a 1:1 ratio and injected into BALB/c nude mice through tail-vein injection. A representative fluorescence micrograph is shown of frozen sections of mouse lung at (A) 0.5 h and (B) 24 h post-tail-vein injection. White arrows indicate the red fluorescent RR-CaSki cells. Scale bar = 200 μm. The results were collected from six mice in each group, and the results were similar. (C) Summary of number of fluorescent cells in lung (red fluorescence indicating RR-CaSki cells vs. green fluorescence indicating WT-CaSki cells). (D) Summary of number of fluorescent cells in lung (red fluorescence indicating RR-CaSki cells transfected with Scrambled NC (100 nM) vs. green fluorescence indicating RR-CaSki cells transfected with Pre miR-29a; 100 nM). Data are the mean ± SD from six independent experiments. * p < 0.05, ** p < 0.05.