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. 2022 May 11;23(10):5382. doi: 10.3390/ijms23105382

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The total expression of proteins from sphingolipid catabolism, e.g., (A) acid ceramidase (ASAH1), (B) acid ceramidase (ASAH2), (C) sphingosine kinase 1 (SPHK1), and (D) sphingosine kinase 2 (SPHK2), in the subcutaneous (SAT) and visceral (VAT) adipose tissues of rats fed a standard diet (control) or high-fat diet (HFD) after chronic CBD treatment. The total expression of the above proteins was standardized to the total protein expression, and the control group was set to 100%. The data are expressed as mean values ± SD, n = 6 in each group. ^a p < 0.05: significant difference: control group vs. experimental group; ^b p < 0.05: significant difference: HFD vs. HFD+CBD.