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Biogenesis and biological function of miRNAs. RNA Pol II: RNA polymerase II; DGCR8: DiGeorge syndrome critical region 8; pri-miRNAs: primary miRNA; pre-miRNAs: microRNAs precursor; RISC: RNA-induced silencing complex; TRBP: TAR RNA binding proteins; AGO2: Argonaute 2; ORF: open reading frame.
