Table 2.
Cytokines and mediators produced by uterine mast cells and macrophages during the different phases of the menstrual cycle under physiological conditions. Abbreviations: uMɸs (uterine Mɸs); uMCs (uterine MCs); mMCs (myometrial MCs) [64,68,69,70,71,74,75,76,77,78].
| Phase | Cell | Molecules/Status | Ref. |
|---|---|---|---|
| Proliferative | uMϕ | TNF-α; IL-1β; IL-10; IL-1RA; VEGF; FGF2; PDFG; phagocytosis; CD69; CD71; CD54 |
[69,70,71] |
| Proliferative | uMC | Steady state | [68] |
| Secretory | uMϕ | IL-11; activin; CD163 (70%) | [71,74,75,76] |
| Mid-late secretory | uMC | Tryptase; chymase; TNF-α; histamine; heparin | [68] |
| Menstrual repair | uMϕ | TNF-α; MMP-9; MMP-12; MMP-14 Phagocytosis; TIMP; VEGF |
[64,77,78] [78] |
| Menstrual | mMC | Tryptase; chymase | [68] |