Figure 1.

Effect of chronic dapagliflozin (Dapa) administration on salt-induced hypertension in male Dahl salt-sensitive rats. A: schematic representation of the experimental protocol. B and C: the development of mean arterial blood pressure (MAP; B) and heart rate [HR; in beats/min (bpm); C] in Dahl salt-sensitive rats after a diet change from a normal-salt (NS; 0.4% NaCl, day 0) diet to a high-salt (HS; 4% NaCl) diet and chronic treatment with Na⁺-glucose cotransporter-2 inhibitor (Dapa) or vehicle. D: changes in MAP (Δ) in weeks 1, 2, and 3 of Dapa treatment on the HS diet (for baseline MAP on the NS diet was used). E: pressure-natriuresis curve from the NS diet (baseline) to 3 wk on the HS diet between vehicle- and Dapa-treated rats. n = 10–11 rats per group. **P < 0.01 and ***P < 0.001 (ANOVA).