Effect of chronic dapagliflozin administration on body composition and diuresis in Dahl salt-sensitive (SS) rats. A–C: total body weight (TBW; A), two-kidney weight normalized to body weight (2Kidney/BW; B), and heart weight normalized to body weight (heart weight/BW; C) in Dahl SS rats following 21 days of the high-salt (HS) diet. Also shown is the 2 kidney-to-body weight ratio in Dahl salt-sensitive rats fed a normal-salt (NS) diet. D: 24-h urine volumes of Dahl SS rats at days 0, 7, 14, and 21 following the HS challenge. E: urinary glucose concentrations at days 0, 7, 14, and 21 of the HS diet. n = 10–11. **P < 0.01 and ***P < 0.001. ns, not significant.