Figure 5.

Urine electrolytes normalized to creatinine in Dahl salt-sensitive rats under Na⁺-glucose cotransporter-2 inhibitor treatment. Electrolytes were measured at days 0, 7, 14, and 21 of the high-salt (HS) diet. A: Na⁺. B: Cl⁻. C: K. D: Ca²⁺. Also shown are values for Mg²⁺ (E), $\mathrm{P}{\mathrm{O}}_4^3{}^{{}^{{}_{-}}}$ (F), and uric acid (G) on day 21 of the HS diet. H: fractional excretion (FE) of Na⁺, Cl⁻, K⁺, Ca²⁺, Mg²⁺, $\text{P}{\text{O}}_4^3{}^{{}^{{}_{-}}}$, and uric acid over a 24-h period in vehicle- and dapagliflozin-treated Dahl salt-sensitive rats. n ≥ 5. Cre, creatinine; ns, not significant.