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. 2022 Apr 25;322(6):F692–F707. doi: 10.1152/ajprenal.00053.2022

Figure 6.

Figure 6.

Renin-angiotensin-aldosterone system metabolites in Dahl salt-sensitive rats treated with dapagliflozin or vehicle on day 21 of the high-salt diet. A: equilibrium levels of ANG I (1−10), ANG II, ANG III (2−8), ANG (1–7), ANG IV (3–8), and ANG (1−5). B: summary graph of plasma aldosterone levels in Dahl salt-sensitive rats. C: ratio of ANG II to ANG I representing ACE activity. D: adrenal response to ANG II (AA2 ratio) of aldosterone and ANG II. E: sum of ANG I and ANG I demonstrating the plasma renin activity (PRA). Triangles on the graphs indicate that levels were at or below lower limits of quantification [<3.0 pM for ANG (1−7), <2.5 pM for ANG II (2−8), <2.0 pM for ANG IV (3−8), and <20.0 pM for aldosterone]. n ≥ 6. ACE, angiotensin-converting enzyme; APA, aminopeptidase A; APN, aminopeptidase N; ns, not significant.