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. 2021 Feb 17;42(5):1557–1568. doi: 10.1007/s10571-021-01046-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — EphA4 regulates neurite outgrowth and regeneration by binding with the ephrin-B ligand of astrocytes. a In the neuron and damaged astrocyte coculture system, EphA4 blocked neurite outgrowth, and interference with ephrin-B ligands on the surface of astrocytes significantly promoted neurite outgrowth. b In the spinal cord slice and damaged astrocyte coculture system, only interference with ephrin-B1 promoted neurite regeneration in the spinal cord slices, however, interference with ephrin-B ligands on the surface of astrocytes significantly promoted neurite outgrowth with the EphA4 Fc stimulation. N = 5; *^{, #}P < 0.05, **^{, ##}P < 0.01, *vs. control, ^#vs. epha4 Fc. Scale bar: 20 or 50 μm