Fig. 5.

The effect of inhibition of cytokines and CSPG in astrocytes on the regulation of neurite outgrowth and regeneration. a In the neuron and damaged astrocyte coculture system, the interference of inflammatory factor expression at 4 h and deletion of CSPG after astrocyte injury promoted neurite outgrowth. b In the spinal cord slice and damaged astrocyte coculture system, the interference of inflammatory factor expression at 24 h after astrocyte injury was only conducive to promoting neurite regeneration, however, interference with inflammatory factor and CSPG expression significantly promoted neurite outgrowth with the EphA4 Fc stimulation. N = 5; *^{, #}P < 0.05, **^{, ##}P < 0.01, *vs. control, ^#vs. epha4 Fc. Scale bar: 20 or 50 μm