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. 2022 May 27;12:8971. doi: 10.1038/s41598-022-12705-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomics-identified differences between untreated PGCC and PGCC treated with LCL521 for 5 h. (A) Four mRNAs were increased by LCL521 exposure in the PGCC population while none were altered by the drug exposure in the parental PPC1 population. (B) Summary of the four upregulated genes in PGCC; all genes were upregulated upon LCL521 treatment. Values in PGCC and PGCC treated with LCL521 as well as the adjusted p-value are shown with p values adjusted using the Benjamini and Hochberg approach for controlling the false discovery rate. (C) Graphical representation of change magnitude for the four significantly upregulated mRNAs in PGCC. (D) qPCR analysis of HMCGR and INSIG1 in MEL624 PGCC generated through radiation and left untreated or exposed to 5 μM LCL521 for 5 h.