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. 2022 May 27;12:8971. doi: 10.1038/s41598-022-12705-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Simvastatin alone inhibits PGCC division. (A) 10X images of parental PPC1 cells or PGCC treated with DMSO or simvastatin. Daughter cells are shown mid-extrusion from DMSO treated PGCC while simvastatin treated PGCC lack progeny. (B) Growth inhibition in parental PPC1 exposed to simvastatin is quantified by the crystal violet viability assay, with DMSO treatment set at 100% viable. (C) Colony counts of filtered PGCC are quantified, with at least three independent experiments represented. (D) 10X images of parental MEL624 cells or their PGCC treated with DMSO or simvastatin. Statin-treated parental cells show slight growth inhibition as quantified in (E). Statin-treated PGCC show a loss of colony formation as quantified in (F), representing at least three independent experiments. ***p < 0.001, ****p < 0.0001.