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Insensitivity of H3 and G4 clones to TMS. Flow cytometry of (A) G4 clone #1 untreated cells; (B) G4 clone #1 cells treated with TMS; (C) G4 clone #6 untreated cells; (D) G4 clone #6 cells treated with TMS; (E) H3 untreated cells, early passage; (F) H3 cells treated with TMS; (G) H3 untreated cells, late passage; (H) percent sub-G1 cells in control (minus ectopic site non–B-DNA), H3, and G4 cells. ∗p < 0.005; ∗∗p < 0.0002. n ≥ 3. G4, G-quadruplex; H3, triplex; TMS, telomestatin.
