Figure 5.

Systemic evaluation of parameter contributions to model behavior

Parameter sensitivity was evaluated by running simulations for perturbations in the parameters $D_{virus},{\lambda }_{virus},\beta ,$ and $\alpha$. Each parameter was perturbed by $\left[0.1,0.5,1,1.5,2,10\right]\times p$, where $p$ is the parameters original value (see Table S2). The average remaining glioblastoma cells on day 3 from 10 simulations are reported in the heatmaps (left). The corresponding model spatial tumor configuration for an instance of a parameter value is given in the heatmaps for (A) fully dense sample 100:0, (B) fully sparse sample 0:100, and (C) patchy 50:50 (dense:space).