Figure 3.

Selective loss of progesterone receptor by maternal FOXP3+ cells unleashes activation and decidual infiltration of CD8+ T cells with fetal specificity

(A) Number of H-2K^b:OVA_257-264 CD8+ T cells in the spleen and peripheral lymph nodes or decidua and CXCR3 gMFI by H-2K^b:OVA_257-264 CD8+ T cells in the spleen and lymph nodes of FOXP3-WT (black) or FOXP3-PRKO (red) female during allogeneic pregnancies (E11.5) sired by Balb/c-2W1S/OVA (H-2^d) male mice.

(B) Percent fetal wastage, number of live pups in utero, and concepti at mid-gestation following once weekly administration of anti-CXCR3 (open) or isotype (filled) antibodies in FOXP3-PRKO females initiated at time of mating with Balb/c-2W1S/OVA (H-2^d) male mice. Data are from at least three independent experiments, each with similar results, with each point representing data from an individual mouse. Bar, mean ± SEM. ∗p < 0.05, ∗∗p < 0.01.