Figure 4.

Mediating effect of TRD status on all-cause mortality^a-c

^a The values are binary probit estimates illustrating the total, direct and mediated effects of TRD on mortality event through the post-index acquisition of new physical disorders and psychiatric conditions among matched incident patients in 2014. Total effect was the sum of direct effect and indirect effects via two mediators, whilst the indirect effect was the product of β values in the association between TRD and mediator and, between mediator and mortality.

^b Path model adjusted for post-matching acquisition of new physical disorders before the index date as confounder control.

^c Physical disorders include myocardial infarction, congestive heart failure, peripheral vascular siease, cerebrovascular disease, dementia, chronic pulmonary disease, connective tissue disease, ulcer disease, liver disease, diabetes, hemiplegia or paraplegia, moderate-to-severe renal disease, tumours, leukaemia, lymphoma and acquired immunodeficiency syndrome. Mental health conditions include attention-deficit-hyperactivity disorder, autism, psychosis, schizophrenia, epilepsy, anxiety disorder and personality disorder.

Abbreviations = CFI – Comparative fit index, RMSEA – Root-mean-square error of approximation, TLI – Tucker-Lewis index.