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. 2022 May 16;42(5):220–234. doi: 10.1089/jir.2021.0214

FIG. 2.

FIG. 2.

The DEGs between the LM and PC groups of the MCC cohort dataset. GSE131418 from the GEO database was extracted. The sample data of the MCC cohort were extracted as the discovery group and the sample data of the CON cohort were extracted as the verify group. To observe the distribution of the expression and grouping of samples, a box plot and principal component analysis diagram were constructed through the FactoMineR package of R language. The classical Bayesian modified T-test and provided limma package of R language were applied to screen the DEGs between the LM and PC groups, and the screening criteria were |logFC| > 1 and P < 0.05. A total of 268 DEGs were obtained, containing 173 upregulated and 95 downregulated DEGs. (A) The box plot of samples of the MCC cohort dataset; (B) the box plot of samples of the CON cohort dataset; (C) the principal component analysis diagram of the samples of the MCC cohort dataset; (D) the principal component analysis diagram of the samples of the CON cohort dataset; (E) the principal component analysis diagram of the total samples. (F) Heat map of the DEGs; (G) volcano plot of the DEGs. CON, Consortium; DEGs, differentially expressed genes; GEO, Gene Expression Omnibus; LM, lung metastasis; MCC, Moffitt Cancer Center; PC, primary cancer.