Skip to main content
. 2022 May 16;33(9-10):550–559. doi: 10.1089/hum.2021.274

Figure 2.

Figure 2.

Regional deposition of AAV1.SERCA2a in the lungs. (A) The lung of each endobronchially treated pig was removed and divided into 17 regions. The numbers indicate the locations from where the samples were taken for molecular and histological analyses. Region 17 (not included in the top image) is the accessory lobe that is common in pigs. The figure was adapted from Ref.31 and modified. (B) Quantitative analysis of vgc in DNA extracted from the lung regions from 4 pigs. (C) Quantitative analysis of hSERCA2a mRNA in real-time qPCR (n = 6 for saline-treated and n = 11 for AAV1.SERCA2a-treated lung tissue areas). Data are mean ± SEM, and individual values were analyzed using the Mann–Whitey test. **p < 0.01. mRNA, messenger RNA; qPCR, quantitative polymerase chain reaction; SEM, standard error of the mean; vgc, viral genome copies.