Table 3.

Univariable and multivariable logistic regression analysis with TSH >3.74 mIU/L, TAI and IH as dependent outcomes.

Independent variables	Univariable analysis						Multivariable analysis
	Dependent outcomes						Dependent outcomes
	TSH >3.74 mIU/L		TAI		IH		TSH >3.74 mIU/L		TAI
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	aOR (95% CI)	P	aOR (95% CI)	P
Female foetus	0.81 (0.52–1.25)	0.337	0.71 (0.49–1.04)	0.082	0.55 (0.16–1.89)	0.344
Male foetus	1.24 (0.80–1.94)	0.337	1.40 (0.96–2.05)	0.082	1.81 (0.53–6.22)	0.344
GA @ blood sampling (<9 >13 weeks)	1.37 (0.87–2.15)	0.173	/		1.07 (0.33–3.51)	0.914
Maternal age (years)	0.98 (0.94–1.02)	0.317	1.05 (1.01–1.08)	0.008	1.08 (0.98–1.20)	0.124			1.05 (1.02–1.09)	0.001
BMI (kg/m2)	1.01 (0.96–1.05)	0.744	0.95 (0.91–0.99)	0.022	1.07 (0.97–1.18)	0.201			0.95 (0.90–0.99)	0.015
Caucasian background	1.52 (0.94–2.44)	0.090	1.64 (1.10–2.50)	0.017	0.73 (0.16–3.38)	0.684			1.60 (1.06–2.41)	0.027
Smoking (yes/no)	1.59 (0.93–2.73)	0.091	1.51 (0.94–2.41)	0.087	0.56 (0.07–4.41)	0.584
Parity (n)	0.73 (0.58–0.92)	0.007	0.93 (0.79–1.10)	0.406	1.43 (0.98–2.09)	0.063	0.74 (0.59–0.92)	0.080
TAI	2.40 (1.26–4.56)	0.008	/		5.10 (1.33–19.49)	0.017	2.34 (1.23–4.47)	0.010

Results are given as odds ratios (OR) (95% CI); P values. Bold indicates statistical significance.

FT4, free thyroxine; GA, gestational age; IH, isolated hypothyroxinaemia (TSH level <3.74 mIU/L and FT4 <10.29 pmol/L); TAI, thyroid autoimmunity (TPOAb ≥ 60 kIU/L); TPOAb, thyroid peroxidase autoantibodies; TSH, thyrotropin.