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. 2022 May 19;14(5):1094. doi: 10.3390/v14051094

Figure 1.

Figure 1

Nuclear export of human retroviral gRNA. (A). The mapped domains in the HIV-1 Rev and HTLV-1 Rex proteins. Nuclear localization signal (NLS) Nuclear export signal (NES) (B). The secondary structure of the HIV-1 RRE and HTLV-1 RxRE. Rev responsive element (RRE) Rex responsive element (RxRE) See text for further details. Note that the RRE and RxRE structures are not drawn to scale. DEAD box helicase 1 (DDX1), DEAD box helicase 3 (DDX3), HIV Tat-specific factor 1 (Tat-SF1), Chromosomal Maintenance 1, also known as Exportin 1 (CRM1), Ras-related Nuclear protein (Ran), Ran Guanine nucleotide exchange factor (Ran-GEF), Ran GTPase activating protein (Ran-GAP), Eukaryotic translation initiation factor 5A (eIF5A). Created with BioRender.com software (accessed on 4 May 2022).